It is advisable to apply Biobase in a moist state. The patient’s own blood or blood plasma should be used. If neither option is available in sufficient quantities, a sterile isotonic saline solution may be used.

A mixture of Biobase and spongiosa in a ratio of 1:1 is recommended to fill larger defects (>2 cm³).
Local administration of antibiotics is possible.

Figure 1: Dysplasia, proximal tibia

Figure 2: Debridement of the fibrosis, filling the defect with Biobase

Figure 3: After 8 months: visible osseous reorganisation of the granules

Figure 4: After 13 months: bony growth and start of resorption